Accutane is prescribed for the treatment of severe forms of acne, including:
- nodular-cystic acne;
- acne conglobata (confluent acne);
- acne with risk of scars;
- acne not susceptible to other forms of therapy
Pharmacokinetics of Accutane (Isotretinoin)
- Isotretinoin binds with proteins of blood plasma and metabolizes in liver.
- Maximum concentration of the active ingredient Isotretinoin in the blood plasma is reached in 1-4 hours after use of Accutane capsules.
- The active substance Isotretinoin is well digested in the body and rapidly absorbed from the gastrointestinal tract.
- The absorption rate of Isotretinoin may increase with food intake.
- Isotretinoin is excreted from the body within 10-20 hours after the oral intake.
- Most of Accutane drug is excreted with feces, unchanged as a rule, minimum in urine.
The application mode of Accutane (Isotretinoin)
- Accutane medication is taken orally with food, two times a day.
- The initial daily dosage of Accutane is 0,5mg per 1 kg of body mass (person with 80 kg, for instance, must take 1 capsule of Accutane 20mg two times a day).
- The average daily dose of Accutane is 1mg / 1kg of body mass (person with 80 kg has to take one capsule of Accutane 40mg – two times a day).
- Patients with severe forms of body acne, are prescribed the maximum daily dose of Accutane drug – 2mg per 1kg of body weight (patients whose body weight is 80kg, must take two capsules of Accutane 40mg, once – two times a day).
- Maximum recommended duration of treatment course with anti-acne drug Accutane – is 20 weeks (4,5 months).
- In case one achieved the regress of sebaceous glands inflammation on the body and (or) the face earlier than 20 weeks after the first intake of Accutane capsules, the treatment course can be stopped.